Pseudoboehmite as a drug delivery system for acyclovir
نویسندگان
چکیده
Abstract Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir a potent, selective inhibitor of herpes viruses and it indicated for treatment management recurrent cold sores on lips face, genital herpes, other diseases. The problem oral bioavailability acyclovir limited because low permeability across gastrointestinal membrane. use nanoparticles pseudoboehmite as drug delivery system in vitro assays promising approach to further release. Here we report synthesis high purity from aluminium nitrate ammonium hydroxide containing nanoparticles, using sol–gel method, improve systemic acyclovir. presence were verified by infrared spectroscopy, transmission electron microscopy, X-ray diffraction techniques. In vivo tests performed with Wistar rats compare release acyclovir, without addition pseudoboehmite. administration increased content 4.6 times plasma after 4 h administration. We determined that toxicity up 10 mg/mL, gel dried nanoparticles.
منابع مشابه
preparation and characterization of acyclovir loaded nano-niosomes as a potential antiviral drug delivery system
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: ['2045-2322']
DOI: https://doi.org/10.1038/s41598-021-94325-y